Nytol One-A-Night 50mg – 20 Tablets

Due to the nature of this medication the quantity is limited to ONE pack. If more than one is required please contact the pharmacy team and they will assess your requirements – https://www.weldricks.co.uk/customer-care (select Online medicine advice from the dropdown menu)

Nytol One-A-Night is a clinically proven sleep aid that can help relieve temporary sleeplessness and lull you into your regular sleep rhythm.

Nytol One-A-Night may be a better solution for you if you’ve used sleeping aids in the past, or are looking for a convenient dosage as part of your bedtime routine. Simply taking a single tablet 20 minutes before bed can help you drift off towards the land of nod and restful sleep.

The commonly used antihistamine is diphenhydramine hydrochloride.

It blocks the normal actions of histamine, the chemical that stimulates arousal-promoting areas of the brain. This helps reduce alertness and promote that first drowsy stage of sleep. And once in that first stage of sleep, most people drift off naturally into restful deeper sleep.

Nytol One-A-Night should be used with caution in patients with:

• Myasthenia gravis
• Epilepsy or seizure disorders
• Narrow-angle glaucoma
• Prostatic hypertrophy, urinary retention
• Asthma, bronchitis, and chronic obstructive pulmonary disease (COPD)
• Moderate to severe hepatic impairment and moderate to severe renal impairment

Tolerance may develop with continuous use. Seek medical advice if sleeplessness persists, as insomnia may be a symptom of serious underlying medical illness.

May increase the effects of alcohol, therefore alcohol should be avoided.

Avoid use of other antihistamine-containing preparations, including topical antihistamines and cough and cold medicines.

Use with caution in the elderly, who are more likely to experience adverse effects. Avoid use in elderly patients with confusion.

Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Drug interactions:

• Diphenhydramine may potentiate the sedative effects of alcohol and other CNS depressants (e.g., tranquillizers, hypnotics, and anxiolytics).
• Monoamine oxidase inhibitors (MAOI) prolong and intensify the anticholinergic effects of diphenhydramine. The product should be used with caution with MAOIs or within 2 weeks of stopping an MAOI.
• As diphenhydramine has some antimuscarinic activity, the effects of some anticholinergic drugs (e.g., atropine, tricyclic antidepressants) may be potentiated. Medical advice should be sought before taking diphenhydramine with such medicines.
• Diphenhydramine is an inhibitor of the cytochrome P450 isoenzyme CYP2D6. Therefore, there may be a potential for interaction with drugs primarily metabolised by CYP2D6, such as metoprolol and venlafaxine. Diphenhydramine should not be used in patients receiving any of these drugs unless directed by a doctor.

Pregnancy and Lactation:

• Diphenhydramine crosses the placenta. Use of sedating antihistamines during the third trimester may result in reactions in the newborn or premature neonates. Consult a doctor before use during pregnancy.
• Diphenhydramine has been detected in breast milk. Nytol One-A-Night is not recommended for use during lactation in nursing mothers. Consult a doctor before use.

Effects on driving and machinery:

Nytol One-A-Night is a hypnotic and will produce drowsiness or sedation soon after the dose has been taken. It may also cause dizziness, blurred vision, cognitive and psychomotor impairment. These can seriously affect the patient's ability to drive and use machines. If affected, do not drive or operate machinery.

Overdose:

Overdose is likely to result in effects similar to those listed under adverse reactions. Additional symptoms may include mydriasis, fever, flushing, agitation, tremor, dystonic reactions, hallucinations, and ECG changes. Large overdose may cause rhabdomyolysis, convulsions, delirium, toxic psychosis, arrhythmias, coma, and cardiovascular collapse.

Treatment should be supportive and directed towards specific symptoms. Convulsions and marked CNS stimulation should be treated with parenteral diazepam.

Oral administration only.

One tablet to be taken 20 minutes before going to bed, or as directed by a physician.

Do not exceed the stated dose or frequency of dosing.

Do not use in children under 16 years.

Active ingredient: Each tablet contains Diphenhydramine Hydrochloride 50 mg.

Other ingredients: Anhydrous lactose, microcrystalline cellulose, maize starch, stearic acid, and colloidal anhydrous silica.